What is a primary side effect of Cyclosporine, also known as Sandimmune?

Gingival hyperplasia is a well-documented side effect of Cyclosporine, a medication commonly used for its immunosuppressive properties. This condition is characterized by the overgrowth of gum tissue, which can occur due to the medication's impact on inflammatory mediators and growth factors involved in gum tissue health. Cyclosporine can alter the normal balance of these processes, leading to an increase in the proliferation of gingival fibroblasts, which contribute to the thickening and overgrowth of the gums.

The importance of recognizing gingival hyperplasia as a side effect lies in its implications for oral health. Patients taking Cyclosporine should be monitored for changes in their gum tissue, and appropriate dental hygiene practices should be emphasized to mitigate this side effect. Proper oral care, including regular dental check-ups and potential interventions, can help manage gingival overgrowth and maintain overall periodontal health.